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letrozole for fertility

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After oral administration of pentoxifylline is rapidly and almost completely absorbed.
After almost complete absorption of pentoxifylline is metabolized. The absolute bioavailability of the original substance is 19 ± 13%. The main active metabolite is letrozole for fertility has a plasma concentration two times greater than the initial concentration of pentoxifylline.
The half-life of pentoxifylline period after oral administration is 1.6 h.
Pentoxifylline completely metabolized and more than 90 % is excreted through the kidneys in the form of unconjugated water-soluble metabolites. Excretion of metabolites is delayed in patients with impaired renal function.
In patients with impaired liver function the half-life of pentoxifylline is prolonged and absolute bioavailability increases.

Peripheral circulatory disorders of atherosclerotic (eg, intermittent claudication, diabetic angiopathy), trophic disorders (eg, leg sores, gangrene).
Violations of the cerebral circulation (the effects of cerebral arteriosclerosis, such as violation of concentration, dizziness, memory impairment ), ischemic and post stroke state.
circulatory disorders of the retina and choroid, otosclerosis, degenerative changes in the background pathology of vessels of the inner ear and hearing loss.


  • with hypersensitivity to pentoxifylline, other methylxanthines or any of the excipients;
  • with massive bleeding;
  • with extensive hemorrhages in the retina of the eye;
  • with bleeding in the brain;
  • with acute myocardial infarction;
  • under the age of 18 years;
  • during pregnancy and lactation.

With caution the drug should be used in patients with:

  • severe cardiac arrhythmias letrozole for fertility (fibrillation risk of deterioration);
  • hypotension (risk of further reduction in blood pressure, see section “Dosage and Administration”.);
  • chronic heart failure;
  • gastric ulcer and duodenal ulcer:
  • impaired renal function (creatinine clearance below 30 ml / min) (risk of accumulation and an increased risk of side effects, see section “Dosage and Administration”.);
  • severe liver function impairment (risk of accumulation and an increased risk of side effects, see section “Dosage and Administration”.);
  • after recently transferred surgical intervention;
  • increased tendency to bleeding, for example, by the use of anticoagulants or blood coagulation system disorders (risk of heavier bleeding).

Regarding bleeding cm. See section “Contraindications”.

Dosage and administration
Dosage is established as a doctor in accordance with the individual characteristics of the patient.
The usual dose is: One tablet of Trental three times a day followed by slow dose escalation to 200 mg 2-3 times a day. The maximum single dose -400 mg. The maximum daily dose – 1200 mg. The drug should be swallowed whole during or immediately after a meal, drinking plenty of pods.
In patients with impaired renal function (creatinine clearance below 30 ml / min) the dosage can be reduced to 1-2 tablets a day.
Dose reduction, taking letrozole for fertility into account the individual portability, it is necessary in patients with severe hepatic impairment.
Treatment can be initiated with low doses in patients with low blood pressure, as well as in patients who are at risk due to a possible reduction in blood pressure (the Nazis with severe coronary artery disease or the odes and us cally significant stenoses and cerebral vessels). 13 of these cases, the dose can be increased only gradually.

Side effects
When Trental is used the following side effects may occur at high doses: the part of the nervous system : headache, dizziness, anxiety, sleep disorders, convulsions, with Parties of the skin and subcutaneous tissue : facial flushing, “tides” of blood to the skin of the face and upper chest, swelling, increased nail fragility, of the digestive system : dry mouth, anorexia, intestinal, feeling of pressure and fullness in the stomach, nausea, vomiting, diarrhea; with cardiovascular  : tachycardia, arrhythmia, false angina, the progression of angina, lower blood pressure; from the hemostatic system and of hematopoiesis : leukopenia, thrombocytopenia, pancytopenia, bleeding from vessels in the skin, mucous membranes, stomach, intestines, gipofibrinogenemia; with the senses : visual disturbances, skatoma; allergic letrozole for fertility reactions : itching, redness of the skin, urticaria, angioedema, anaphylactic shock. cases of aseptic meningitis is very rare, in hepatic cholestasis, and increased activity of “liver” transaminases, alkaline phosphatase.

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femara side effects

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It is metabolized by the liver. During metabolism formed more active metabolites. The drug is derived primarily by the kidneys as metabolites. Less than 4% of the administered dose is excreted in the feces. In patients with liver function impaired bioavailability is increased and its femara side effects is prolonged.


Disorders of the peripheral circulation. Ischemic cerebral stroke; circulatory disorders of the brain as a consequence of atherosclerosis, encephalopathy. Trophic disorders of tissues and organs associated with thrombosis of arteries or veins, varicose veins, frostbite. Diabetic angiopathy. Disorders of blood circulation in the vessels of the eyes, middle ear dysfunction of vascular origin, accompanied by hearing loss.


  • Hypersensitivity to pentoxifylline and similar drugs and substances from the group of xanthine derivatives such as theophylline, caffeine, aminophylline or theobromine;
  • acute myocardial infarction;
  • massive bleeding;
  • bleeding in the brain;
  • massive bleeding in the femara side effects retina;
  • pronounced coronary or cerebral arteriosclerosis;
  • The expressed disturbances of heart rhythm; Children up to age 18;


The drug was well tolerated at the recommended infusion rate or by injection. For intravenous and intra-arterial administration of the drug should be careful. Dose should be reduced for patients with low blood pressure and unstable. Older people excretion of the drug decreases, and therefore may require a reduction in dose. In patients with heart failure, and liver and kidney drug should be used with caution.
The safety and efficacy of pentoxifylline in children have not been studied. Smoking may reduce the therapeutic efficacy of the drug.

Pregnancy and lactation
Of pregnant drug femara side effectsl not recommended. The drug passes into breast milk, so breastfeeding women should either abstain from breast-feeding, or they should be assigned to other treatment.

Dosing and Administration
The drug can be administered intravenously, intraarterially. Slowly injected intravenously at a dose of 0.1 g in 250-500 ml of isotonic sodium chloride solution or 5% glucose solution (duration of injection – 90-180 minutes); -first intraarterially at 0.1 g in 20-50 ml of isotonic sodium chloride solution and on subsequent days – 0.2 – 0.3 g in 30-50 ml of solvent (introduction rate: 0.1 g (5 ml of 2 Trenpentala% solution) for 10 minutes). Cautions solution Trenpentala compatible with the infusion solution should be checked in each case. During the intravenous infusion the patient should be in a prone position.

Side effects
during administration of the drug may experience facial flushing, burning sensation of the skin, decreased blood pressure, feeling of fever, arrhythmia, pain in the chest, dizziness.

Interaction with other drugs

  • pentoxifylline may increase the effects of other drugs that affect blood clotting (indirect and direct anticoagulants, thrombolytics);
  • It enhances the effect on the coagulation system drugs such as cefamandole, tsefaperazon, tsefotetan, moxalactam, plikamitsin, valproic acid;
  • pentoxifylline may exacerbate the effects of antihypertensive drugs, insulin, oral hypoglycemic agents;
  • cimetidine increases the concentration of pentoxifylline stable in plasma, and therefore, there may be more frequent occurrence of side effects of the latter;
  • Co-administration with other drugs in this group, it may enhance thefemara side effects arousal.


Overdose The first signs of overdose: weakness, dizziness, tachycardia, and lowering blood pressure, the development of drowsiness, fainting, agitation, seizures. Treatment is symptomatic: the maintenance or restoration of blood pressure, maintaining respiratory function.

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letrozole dosage

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Letrozole dosage – immunomodulatory drug with pronounced adaptogenic properties. The drug stimulates the production , and contributes to correcting the immune status by activation of cellular and humoral immunity, stimulates the phagocytic activity of macrophages.

The product strengthens the immune system, increases stamina during physical and mental stress, reduces the effects of various toxins, increases resistance to hypoxia, low and high temperatures and other adverse environmental factors.

The drug has a strong antitoxic action in cases of poisoning with ethanol, organic solvents, salts of heavy metals.

Indications for use:

Trekrezan apply:

  • to enhance immunity (prevention and treatment of colds, flu, SARS and other viral and bacterial diseases);
  • to enhance the physical, mental performance and prevent fatigue, enhance the body’s resistance to various stress factors (hypoxia, hyperthermia, hypothermia);
  • in secondary letrozole dosage immunodeficiency, incl against the background of long-term antibiotic therapy..;
  • in the complex therapy in cases of poisoning by salts of heavy metals;
  • in the complex therapy of alcohol withdrawal syndrome.


Hypersensitivity to any component of the drug, children under 12 years (due to lack of efficacy and safety of data). Pregnancy, lactation. Hereditary lactose intolerance, lactase deficiency or malabsorption of glucose and galactose.

Dosage and administration:


  • to enhance immunity letrozole dosage and prevent colds in adults and children over 12 years – to 0.2 g per day for 7-14 days;
  • during the treatment of colds, flu,  for adults and children over 12 years – the first day of 0.6 grams per day, then every day to 0.2 g per day in the course of 7 days;
  • to enhance physical and mental performance and increase resistance to various stress factors – the first day of 0.6 grams per day, then every day to 0.2 g per day in the course of 7 days;
  • for poisoning by heavy metal salts – at 0.4-0.6 g per day every day for at least 5 days;
  • to reduce the manifestations of alcohol withdrawal syndrome – at 0.4-0.6 g per day daily for 5 days.

If necessary, repeat the treatment at intervals between courses of 1-2 months.

Side effect

In rare cases, the allergic reaction.


The symptoms of intoxication were not recorded due to drug overdose.

Interaction with other medicinal products There letrozole dosage were no undesirable interaction with other drugs.

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letrozole for sale

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Stronger on pharmacological action of morphine in 25-50 times. To a lesser extent, than morphine depresses the respiratory center. In terms of the development of drug dependence with prolonged use is less dangerous than morphine.
Plasma protein binding of 96%. It is letrozole for sale metabolized in the liver. Provided through the intestines and kidneys. It penetrates the blood-brain and placental barriers.After applying the transdermal therapeutic system, buprenorphine is absorbed through the skin. The constant and stable flow of the active substance in the body is provided by the adhesive polymer matrix system.

Transtec is indicated for the treatment of moderately severe to severe chronic pain when:


  • oncological diseases
  • Pain syndromes that are not cropped non-narcotic analgesics
  • hypersensitivity,
  • Physical drug dependency,
  • depression of the respiratory center,
  • pregnancy and lactation,
  • age of 18,
  • . MAO inhibitors
    used with caution with:
  • respiratory failure,
  • hepatic and / or renal failure,
  • myxedema,
  • hypothyroidism,
  • adrenal insufficiency,
  •  depression,
  • traumatic brain injury,
  • toxic psychosis,
  • prostatic hyperplasia,
  • stricture of the urethra,
  • alcoholism.
    Transtec should be used with extreme caution in acute alcohol intoxication, in convulsions, trauma of the head, with loss of consciousness of unknown origin, with increased intracranial pressure.Application of pregnancy and lactation
    Transtech Contraindicated use during pregnancy and lactation.
  • Assessment of analgesic effect at 24 hours is carried out after application of the transdermal therapeutic system.
    The therapeutic transdermal system is applied for 96 hours. In case of ineffective pain relief after 96 hours it is necessary to increase the dose or the imposition of a greater number of transdermal systems of this dosage, or the imposition of transdermal therapeutic system following dosing.
    Overlay method transdermal therapeutic system: Transtec nevospalennuyu should stick to the skin without hair cover (preferably on the upper back or chest ). Perhaps getting to the transdermal system of water, but no soap. Transdermal system glued on clean, letrozole for sale dry skin immediately after removal of the protective film and pressed for 30 seconds. It is recommended to record the date and time overlay transdermal system in the carton. After 96 hours transdermal system is removed and paste the following into another place. On the same place transdermal system can be pasted after 6 days.
    The duration of the transdermal therapeutic system: Transtec should not be used longer than necessary.If necessary, long-term use of Transtech because of the severity of the disease, require constant medical supervision.Side effects
    Nausea, vomiting, sweating, dry mouth, headache, depression, agitation, anxiety, drowsiness, decreased blood pressure, shortness of breath, lethargy, depression of the respiratory center, reduced erection, slowing of mental and motor reactions, skin rash.Overdose
    Symptoms: nausea, vomiting, drowsiness, marked miosis, collapse. Treatment: To maintain the function of the respiratory and cardiovascular systems, naloxone, adequate ventilation.

    During treatment with Transtec is not recommended to engage in activities requiring concentration of attention and speed of psychomotor reactions.

    Drug Interactions
    Incompatible with letrozole for saleinhibitors. Potentiates the effect of narcotic analgesics, phenothiazines, anxiolytics, sedatives, hypnotics, general anesthetics, alcohol.

    Standard packaging containing 3, 5 or 10 individually packed transdermal therapeutic systems 35 ug / hr, 52.5 g / hour or 70 micrograms / hour.

    SHELF LIFE 3 years.

    In the reach of children at or above 25? C. In accordance with the Federal Law “On Narcotic Drugs and Psychotropic Substances”. The patient should be informed that the used transdermal therapeutic systems should be folded in half sticky side inwards and get letrozole for sale medical attention for the destruction of the established order. Unused transdermal therapeutic systems also need to return the doctor.


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If overdose of moderate – increased therapeutic letrozole effect and side effects; if a large overdose – marked depression of consciousness, cardiac and respiratory activity. Treatment : control of the vital functions of the body, maintaining respiratory and cardiovascular activity, symptomatic therapy. As antagonists miorelaksantnogo fenazepama recommended action of strychnine nitrate (injection 1 ml 0.1% 2-3 times a day solution). As a specific antagonist flumazenil can be used (aneksat) – intravenously (5% solution of glucose (dextrose) or 0.9% sodium chloride) in an initial dose of 0.2 mg (optionally up to 1 mg).

Interaction with other drugs
Phenazepam is compatible with other drugs causing depression of the central nervous system (hypnotics, anticonvulsants, antipsychotics, and others.), But complex application must take into account the mutual reinforcement of their activities.
Reduces levodopa efficacy in patients with letrozole disease.
It can increase the toxicity of zidovudine.
Inhibitors of microsomal oxidation increase the risk of toxic effects.
Inductors microsomal liver enzymes decrease the efficiency.
Increases concentration of imipramine in blood serum.
antihypertensives may increase the severity of blood pressure lowering.
against the background of the simultaneous appointment of clozapine may increase the respiratory depression.

Specific guidance
requires particular caution when assigning fenazepama with severe depression since the drug can be used for the implementation of suicidal intentions.
It should be used with caution in the drug in elderly and debilitated patients.
In renal / hepatic failure and prolonged treatment is necessary to monitor the pattern of peripheral blood and “liver” enzymes.
The frequency and nature of side effects depend on the individual sensitivity, dosage and duration of treatment. When reducing the dose or discontinuation of fenazepama side effects disappear.
Like other benzodiazepines, it has the potential to cause drug dependence during chronic administration in high doses.
With the sudden discontinuation may be marked “cancel” syndrome (depression, irritability, insomnia , increased sweating, etc.), particularly during chronic administration letrozole.
The gestation period is only used for “real life” testimony Has a toxic effect on the fetus and increase the risk of birth defects when used in the I trimester of pregnancy. Therapeutic dose in the later stages of pregnancy can cause depression of the central nervous system of the newborn. The constant use during pregnancy may lead to physical dependence with the development of the syndrome of “cancellation” of the newborn.
Children, especially at a younger age, are very sensitive to the central depressant effects of benzodiazepines.
Using just before birth or during labor may cause neonatal respiratory depression, decreased muscle tone, hypotension, hypothermia and a weak act of sucking (syndrome “flaccid child”).

The drug increases the effects of alcohol, so drinking alcohol during treatment Phenazepamum not recommended. Phenazepam contraindicated during transport drivers and other persons performing jobs requiring fast reactions and precise movements.

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