Stronger on pharmacological action of morphine in 25-50 times. To a lesser extent, than morphine depresses the respiratory center. In terms of the development of drug dependence with prolonged use is less dangerous than morphine.
Plasma protein binding of 96%. It is letrozole for sale metabolized in the liver. Provided through the intestines and kidneys. It penetrates the blood-brain and placental barriers.After applying the transdermal therapeutic system, buprenorphine is absorbed through the skin. The constant and stable flow of the active substance in the body is provided by the adhesive polymer matrix system.

INDICATIONS
Transtec is indicated for the treatment of moderately severe to severe chronic pain when:

 

  • oncological diseases
  • Pain syndromes that are not cropped non-narcotic analgesics
  • CONTRAINDICATIONS
  • hypersensitivity,
  • Physical drug dependency,
  • depression of the respiratory center,
  • pregnancy and lactation,
  • age of 18,
  • . MAO inhibitors
    used with caution with:
  • respiratory failure,
  • hepatic and / or renal failure,
  • myxedema,
  • hypothyroidism,
  • adrenal insufficiency,
  •  depression,
  • traumatic brain injury,
  • toxic psychosis,
  • prostatic hyperplasia,
  • stricture of the urethra,
  • alcoholism.
    Transtec should be used with extreme caution in acute alcohol intoxication, in convulsions, trauma of the head, with loss of consciousness of unknown origin, with increased intracranial pressure.Application of pregnancy and lactation
    Transtech Contraindicated use during pregnancy and lactation.
  • Assessment of analgesic effect at 24 hours is carried out after application of the transdermal therapeutic system.
    The therapeutic transdermal system is applied for 96 hours. In case of ineffective pain relief after 96 hours it is necessary to increase the dose or the imposition of a greater number of transdermal systems of this dosage, or the imposition of transdermal therapeutic system following dosing.
    Overlay method transdermal therapeutic system: Transtec nevospalennuyu should stick to the skin without hair cover (preferably on the upper back or chest ). Perhaps getting to the transdermal system of water, but no soap. Transdermal system glued on clean, letrozole for sale dry skin immediately after removal of the protective film and pressed for 30 seconds. It is recommended to record the date and time overlay transdermal system in the carton. After 96 hours transdermal system is removed and paste the following into another place. On the same place transdermal system can be pasted after 6 days.
    The duration of the transdermal therapeutic system: Transtec should not be used longer than necessary.If necessary, long-term use of Transtech because of the severity of the disease, require constant medical supervision.Side effects
    Nausea, vomiting, sweating, dry mouth, headache, depression, agitation, anxiety, drowsiness, decreased blood pressure, shortness of breath, lethargy, depression of the respiratory center, reduced erection, slowing of mental and motor reactions, skin rash.Overdose
    Symptoms: nausea, vomiting, drowsiness, marked miosis, collapse. Treatment: To maintain the function of the respiratory and cardiovascular systems, naloxone, adequate ventilation.

    Cautions
    During treatment with Transtec is not recommended to engage in activities requiring concentration of attention and speed of psychomotor reactions.

    Drug Interactions
    Incompatible with letrozole for saleinhibitors. Potentiates the effect of narcotic analgesics, phenothiazines, anxiolytics, sedatives, hypnotics, general anesthetics, alcohol.

    PACKAGING
    Standard packaging containing 3, 5 or 10 individually packed transdermal therapeutic systems 35 ug / hr, 52.5 g / hour or 70 micrograms / hour.

    SHELF LIFE 3 years.

    STORAGE
    In the reach of children at or above 25? C. In accordance with the Federal Law “On Narcotic Drugs and Psychotropic Substances”. The patient should be informed that the used transdermal therapeutic systems should be folded in half sticky side inwards and get letrozole for sale medical attention for the destruction of the established order. Unused transdermal therapeutic systems also need to return the doctor.