If overdose of moderate – increased therapeutic letrozole effect and side effects; if a large overdose – marked depression of consciousness, cardiac and respiratory activity. Treatment : control of the vital functions of the body, maintaining respiratory and cardiovascular activity, symptomatic therapy. As antagonists miorelaksantnogo fenazepama recommended action of strychnine nitrate (injection 1 ml 0.1% 2-3 times a day solution). As a specific antagonist flumazenil can be used (aneksat) – intravenously (5% solution of glucose (dextrose) or 0.9% sodium chloride) in an initial dose of 0.2 mg (optionally up to 1 mg).
Interaction with other drugs
Phenazepam is compatible with other drugs causing depression of the central nervous system (hypnotics, anticonvulsants, antipsychotics, and others.), But complex application must take into account the mutual reinforcement of their activities.
Reduces levodopa efficacy in patients with letrozole disease.
It can increase the toxicity of zidovudine.
Inhibitors of microsomal oxidation increase the risk of toxic effects.
Inductors microsomal liver enzymes decrease the efficiency.
Increases concentration of imipramine in blood serum.
antihypertensives may increase the severity of blood pressure lowering.
against the background of the simultaneous appointment of clozapine may increase the respiratory depression.
requires particular caution when assigning fenazepama with severe depression since the drug can be used for the implementation of suicidal intentions.
It should be used with caution in the drug in elderly and debilitated patients.
In renal / hepatic failure and prolonged treatment is necessary to monitor the pattern of peripheral blood and “liver” enzymes.
The frequency and nature of side effects depend on the individual sensitivity, dosage and duration of treatment. When reducing the dose or discontinuation of fenazepama side effects disappear.
Like other benzodiazepines, it has the potential to cause drug dependence during chronic administration in high doses.
With the sudden discontinuation may be marked “cancel” syndrome (depression, irritability, insomnia , increased sweating, etc.), particularly during chronic administration letrozole.
The gestation period is only used for “real life” testimony Has a toxic effect on the fetus and increase the risk of birth defects when used in the I trimester of pregnancy. Therapeutic dose in the later stages of pregnancy can cause depression of the central nervous system of the newborn. The constant use during pregnancy may lead to physical dependence with the development of the syndrome of “cancellation” of the newborn.
Children, especially at a younger age, are very sensitive to the central depressant effects of benzodiazepines.
Using just before birth or during labor may cause neonatal respiratory depression, decreased muscle tone, hypotension, hypothermia and a weak act of sucking (syndrome “flaccid child”).
The drug increases the effects of alcohol, so drinking alcohol during treatment Phenazepamum not recommended. Phenazepam contraindicated during transport drivers and other persons performing jobs requiring fast reactions and precise movements.